UJI INHIBISI AKTIVITAS ENZIM α-GLUKOSIDASE SECARA IN VITRO DARI EKSTRAK METANOL DAN FRAKSI-FRAKSINYA DAUN CRYPTOCARYA DENSIFLORA BLUME

NURUL ARIANI, . (2017) UJI INHIBISI AKTIVITAS ENZIM α-GLUKOSIDASE SECARA IN VITRO DARI EKSTRAK METANOL DAN FRAKSI-FRAKSINYA DAUN CRYPTOCARYA DENSIFLORA BLUME. Sarjana thesis, UNIVERSITAS NEGERI JAKARTA.

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Abstract

Tumbuhan Cryptocarya desiflora Blume digunakan dalam penelitian antidiabetes dengan metode inhibisi aktivitas enzim α-glukosidase secara in vitro. Penelitian ini bertujuan untuk mendapatkan profil fitokimia ekstrak metanol dan fraksifraksinya (n-heksana, n-heksana-etil asetat, serta etil asetat) dari daun Cryptocarya densiflora Blume dan data tentang inhibisi aktivitas enzim αglukosidase dari ekstrak dan fraksi-fraksinya tersebut. Hasil penelitian menunjukkan bahwa fraksi etil asetat mengandung senyawa golongan flavonoid, fenolik, saponin, dan tanin. Fraksi etil asetat berpotensi sebagai inhibitor enzim αglukosidase dengan nilai IC50 sebesar 93,325 ppm dengan kategori aktif sebagai antidiabetes. The Cryptocarya desiflora Blume plant was used in antidiabetic research by inhibition method of α-glucosidase enzyme activity in vitro. The aim of this study was to obtain the phytochemical profile of methanol extract and its fractions (nhexane, n-hexane-ethyl acetate, and ethyl acetate) from Cryptocarya densiflora Blume leaf and data on inhibition of α-glucosidase enzyme activity of extracts and fractions. The results showed that ethyl acetate fraction contains flavonoids, phenolic, saponin, and tannin compounds. Ethyl acetate fraction has the potential of α-glucosidase enzyme inhibitor with 93,325 ppm of IC50 value with active category as antidiabetic.

Item Type: Thesis (Sarjana)
Additional Information: 1) Irma Ratna Kartika, M.Sc.Tech 2) Dr. Fera Kurniadewi, M.Si
Subjects: Sains > Kimia
Divisions: FMIPA > S1 Kimia
Depositing User: sawung yudo
Date Deposited: 13 Apr 2022 02:31
Last Modified: 13 Apr 2022 02:31
URI: http://repository.unj.ac.id/id/eprint/26417

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