KAJIAN PATOLOGI ANATOMI DAN HISTOPATOLOGI DUODENUM MENCIT (Mus musculus) YANG DIINFEKSI TELUR CACING CESTODA DAN DIBERI EKSTRAK DAUN KELOR (Moringa oleifera Lam.) DOSIS LETHAL 100

DANIEL RAMADHAN, . (2023) KAJIAN PATOLOGI ANATOMI DAN HISTOPATOLOGI DUODENUM MENCIT (Mus musculus) YANG DIINFEKSI TELUR CACING CESTODA DAN DIBERI EKSTRAK DAUN KELOR (Moringa oleifera Lam.) DOSIS LETHAL 100. Sarjana thesis, UNIVERSITAS NEGERI JAKARTA.

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Abstract

Penyakit kecacingan yang disebabkan oleh infeksi cacing cestoda disebut cestodiasis. Infeksi dari cacing cestoda dapat memengaruhi kondisi dan struktur dari saluran pencernaan hewan, khususnya usus. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh dari pemberian ekstrak daun kelor LD100 terhadap perbaikan kondisi dan struktur duodenum mencit cestodiasis. Penelitian ini menggunakan 3 kelompok perlakuan yaitu Kontrol (-) (mencit cestodiasis+aquades), Kontrol (+) (mencit cestodiasis+albendazole), dan Kelompok mencit cestodiasis yang diberi ekstrak daun kelor LD100 sebesar 500 ppm. Penginfeksian 40 butir telur cacing cestoda dilakukan pada hari ke-8, dan pemberian ekstrak daun kelor LD100 sebesar 500 ppm dilakukan pada hari ke-9 dan ke-18 secara oral. Parameter dalam penelitian ini meliputi kondisi patologi anatomi, histopatologi, dan histomorfometri struktur duodenum mencit cestodiasis yang diukur bersamaan dengan kondisi histopatologi. Hasil penelitian menunjukkan pengaruh ekstrak daun kelor LD100 sebesar 500 ppm memperbaiki kondisi patologi anatomi sebesar 25%, kondisi histopatologi dengan mengurangi gejala infeksi berupa ulserasi dan deskuamasi epitel menjadi 0% dan 25%, serta histomorfometri masuk dalam kategori normal. Dari setiap kelompok perlakuan, ada perbedaan secara nyata dari kondisi patologi anatomi, histopatologi, dan histomorfometri struktur duodenum mencit cestodiasis (Sig <0.05). Pemberian ekstrak daun kelor LD100 sebesar 500 ppm dapat memperbaiki kondisi patologi anatomi dan histopatologi serta memperbaiki struktur duodenum mencit cestodiasis. Worm disease caused by infection of cestode worms is called cestodiasis. Cestode worms infection can affect the condition and structure of the animals digestive tract, especially the intestines. The purposes of this study is to determine the effects of giving LD100 moringa leaf extract to repair the condition and structure of duodenal of the cestodiasis mice. This study used 3 treatment groups, namely Control (-) (cestodiasis mice + aquades), Control (+) (cestodiasis mice + albendazole), and Cestodiasis mice group which was given a LD100 moringa leaf extract in the amount of 500 ppm. Infection of 40 cestode worm eggs was carried out on the 8th day, and given a LD100 moringa leaf extract in the amount of 500 ppm was carried out on the 9th and 18th days orally. Parameters in this study included pathological anatomy, histopathological, and histomorphometry of the duodenal structures of cestodiasis mice that measured alonng with histopathological condition. The results showed that the effect of LD100 moringa leaf extract in the amount of 500 ppm repair pathological anatomy conditions by 25%, histopathological conditions by reducing symptoms of infection in the form of ulceration and epithelial desquamation to 0% and 25%, and histomorphometry was included in the normal category. From each treatment group, there are significant differences in the conditions of pathological anatomy, histopathological, and histomorphometric of the duodenal structures of cestodiasis mice (Sig <0.05). The given of LD100 moringa leaf extract in the amount of 500 ppm could repair the conditions of pathological anatomy and histopathological as well as to repair the duodenal structure of cestodiasis mice.

Item Type: Thesis (Sarjana)
Additional Information: 1). drh. Atin Supiyani, M.Si.; 2). Drs. Refirman Dj, M. Biomed.
Subjects: Sains > Ilmu Bumi > Biologi
Divisions: FMIPA > S1 Biologi
Depositing User: Users 17187 not found.
Date Deposited: 01 Mar 2023 06:20
Last Modified: 01 Mar 2023 06:20
URI: http://repository.unj.ac.id/id/eprint/37390

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