PERUBAHAN PERILAKU, RESPON FISIOLOGIS, DAN SEL IMUN AKIBAT BERBAGAI JENIS STRESOR AKUT PADA MENCIT (MUS MUSCULUS)

FRANSISCA ENDAH PUJIASTUTI, . (2023) PERUBAHAN PERILAKU, RESPON FISIOLOGIS, DAN SEL IMUN AKIBAT BERBAGAI JENIS STRESOR AKUT PADA MENCIT (MUS MUSCULUS). Sarjana thesis, UNIVERSITAS NEGERI JAKARTA.

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Abstract

Respon stres pada hewan penelitian dapat disebabkan oleh stresor yang berasal dari eksternal tubuh. Stres yang terjadi secara akut dapat memengaruhi perilaku, kondisi fisiologis, dan sistem kekebalan tubuh primer. Tujuan penelitian ini untuk mengetahui pengaruh pemberian stresor akut (heat stress, forced swim test, dan noise stress) terhadap perubahan perilaku, laju pernapasan, dan indeks stres mencit. Penelitian ini menggunakan 3 kelompok perlakuan heat stress (43 C), forced swim test (pada air 25 C), dan noise stress (100 dB) dengan pengamatan perilaku, laju napas, suhu tubuh, dan ulas darah saat sebelum dan sesudah perlakuan. Pemberian perlakuan heat stress selama 15 menit, forced swim test 6 menit, dan noise stress 4 jam yang dilakukan selama 1 minggu untuk setiap kelompok perlakuan. Parameter dalam penelitian ini meliputi perubahan perilaku, laju napas, dan indeks stres (N/L) saat kondisi sebelum dan sesudah perlakuan. Hasil penelitian menunjukkan pengaruh perilaku grooming, istirahat, eksplorasi, makan dan minum serta adanya pengaruh stres terhadap laju napas dan indeks stres mencit setelah perlakuan (Sig. <0,05). Pemberian stres akut (heat stress, forced swim test, dan noise stress) memberikan perubahan pada perilaku, serta peningkatan pada laju napas, dan indeks stres (N/L) mencit. **** The stress response in research animals can be caused by stressors external to the body. Acute stress can affect behavior, physiological conditions, and the primary immune system. The purpose of this study was to determine the effect of acute stressors (heat stress, forced swim test, and noise stress) on changes in behavior, respiratory rate, and stress index of mice. This study used 3 treatment groups of heat stress (43 C), forced swim test (with water temperature 25 C), and noise stress (100 dB) with observations of behavior, breathing rate, body temperature, and blood tests before and after treatment. Heat stress treatment for 15 minutes, forced swim test for 6 minutes, and noise stress for 4 hours were conducted for 1 week for each treatment group. Parameters in this study include changes in behavior, breath rate, and stress index (N/L) during pre- and post-treatment conditions. The results showed the effect of grooming, resting, exploration, eating and drinking behavior and the effect of stress on the breath rate and stress index of mice after treatment (Sig. <0.05). Giving acute stress (heat stress, forced swim test, and noise stress) provides changes in behavior, as well as an increase in the breath rate, and stress index (N/L) of mice.

Item Type:	Thesis (Sarjana)
Additional Information:	1). drh. Atin Supiyani, M.Si. ; 2). Drs. Refirman Djamahar, M.Biomed.
Subjects:	Sains > Sains, Ilmu Pengetahuan Alam Sains > Fisiologi
Divisions:	FMIPA > S1 Biologi
Depositing User:	Users 19541 not found.
Date Deposited:	06 Sep 2023 01:20
Last Modified:	06 Sep 2023 01:20
URI:	http://repository.unj.ac.id/id/eprint/40614

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