HISTOLOGIS TESTIS MENCIT (Mus musculus albinus) SETELAH PEMBERIAN EKSTRAK KEDELAI (Glycine max (L.) Merr.) IRADIASI GAMASUGEN 1 DAN 2

PAULINA ARTANA GRESYA, . (2024) HISTOLOGIS TESTIS MENCIT (Mus musculus albinus) SETELAH PEMBERIAN EKSTRAK KEDELAI (Glycine max (L.) Merr.) IRADIASI GAMASUGEN 1 DAN 2. Sarjana thesis, UNIVERSITAS NEGERI JAKARTA.

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Abstract

Kedelai iradiasi Gamasugen 1 dan 2 memiliki kandungan nutrisi yang baik untuk kesehatan. Kedelai mengandung isoflavon yang memberi efek estrogenik dan antiestrogenik yang berpengaruh sekresi sel Leydig dalam sintesis testosteron dan sel Sertoli. Tujuan dari penelitian ini adalah untuk mengetahui adanya pengaruh pemberian ekstrak kedelai iradiasi Gamasugen 1 dan 2 dengan dosis 500 mg/kgBB dan 1000 mg/kgBB terhadap histologis testis mencit. Metode penelitian yang digunakan yaitu eksperimental dengan desain RAL. Penelitian ini dilakukan uji fitokimia dan toksisitas ekstrak kedelai, serta melihat pengaruhnya terhadap testis mencit, berupa morfometri testis, jumlah sel spermatogenik, jumlah sel Sertoli dan sel Leydig. Hasil penelitian dianalisis statistik menggunakan One Way ANOVA dan uji lanjut LSD. Hasil menunjukan ekstrak kedelai Gamasugen 1 dan 2 dosis 500mg/kgBB dan 1000mg/kgBB memberi perbedaan terhadap gambaran histologis testis mencit yang dianalisis dengan penghitungan sel spermatogenik, sel Leydig, dan sel Sertoli (p<0,05). Ekstrak kedelai Gamasugen 1 dan 2 dapat meningkatkan sel-sel spermatogenik testis mencit. Kata kunci: Gamasugen, histologis, kedelai, mencit, testis Gamasugen 1 and 2 irradiated soybeans contain nutrients that are good for health. Soybeans contain isoflavones which have estrogenic and antiestrogenic effects which influence the secretion of Leydig cells in the synthesis of testosterone and Sertoli cells. The aim of this research was to determine the effect of giving irradiated soybean extract Gamasugen 1 and 2 at doses of 500 mg/kgBW and 1000 mg/kgBW on the histology of mouse testes. The research method used is experimental with a RAL design. This research carried out phytochemical and toxicity tests on soybean extract, and looked at its effect on mouse testes, in the form of testicular morphometry, number of spermatogenic cells, number of Sertoli cells and Leydig cells. The research results were statistically analyzed using One Way ANOVA and LSD test. The results showed that Gamasugen 1 and 2 soybean extracts at doses of 500mg/kgBW and 1000mg/kgBW made a difference in the histological picture of mouse testes which was analyzed by counting spermatogenic cells, Leydig cells and Sertoli cells (p<0.05). Gamasugen 1 and 2 soybean extracts can increase spermatogenic cells in mice testicles. Keywords:, Gamasugen, histological, soybean, mice, testes.

Item Type:	Thesis (Sarjana)
Additional Information:	1) Dr. Elsa Lisanti, M.Si. 2) Dr. Rusdi, M.Biomed.
Subjects:	Sains > Sains, Ilmu Pengetahuan Alam Sains > Ilmu Bumi > Biologi Sains > Zoologi
Divisions:	FMIPA > S1 Biologi
Depositing User:	Users 21643 not found.
Date Deposited:	02 Feb 2024 05:08
Last Modified:	02 Feb 2024 05:08
URI:	http://repository.unj.ac.id/id/eprint/44261

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