EFEKTIFITAS HEPATOPROTEKTIF EKSTRAK KUNYIT (Curcuma domestica), JAHE MERAH (Zingiber officinale Roscoe), TEMULAWAK (Curcuma zanthorrhiza) PADA TIKUS PUTIH (Rattus norvegicus)

Intan Salsabila Putri, . (2023) EFEKTIFITAS HEPATOPROTEKTIF EKSTRAK KUNYIT (Curcuma domestica), JAHE MERAH (Zingiber officinale Roscoe), TEMULAWAK (Curcuma zanthorrhiza) PADA TIKUS PUTIH (Rattus norvegicus). Sarjana thesis, UNIVERSITAS NEGERI JAKARTA.

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Abstract

Penyebab gangguan atau kerusakan hati dikarenakan penggunaan obat-obatan yang bersifat hepatotoksik, hal tersebut dapat dicegah dengan pemberian senyawa antioksidan. Kemampuan antioksidan mampu melindungi sistem biologis terhadap potensi suatu zat toksin. Tujuan penelitian ini adalah mengetahui efektifitas ekstrak kunyit, jahe merah dan temulawak sebagai hepatoprotektif pada tikus putih. Penelitian ini menggunakan metode eksperimental dengan menggunakan rancangan percobaan RAL (Rancangan Acak Lengkap) dengan 2 kelompok kontrol (positif dan negatif) dan 3 kelompok perlakuan yaitu diberikan perlakuan induksi parasetamol 162 mg/200 gram BB dan diinjeksi kan kombinasi ekstrak kunyit, jahe merah dan temulawak dengan konsentrasi 25% : 40% : 35%, 20% : 60% : 20% dan 15% : 45% : 40% dengan dosis 500 mg/kg BB. Data dianalisis menggunakan uji One Way Anova pada α = 0,05 dan dilanjutkan uji Duncan. Hasil penelitian menunjukkan kadar SGOT pada tikus yang diberi parasetamol dan kombinasi ekstrak kunyit, jahe merah dan temulawak berada pada 12,2-65,3 IU/L, sedangkan kadar SGPT berada pada 5,3-13,08 IU/L dan kadar Bilirubin total berada pada 0,66-0,68 mg/dl. Hasil Uji One Way Anova kadar SGOT dan Bilirubin Total tidak terdapat beda nyata antar kelompok perlakuan (sig.>0,05), pada kadar SGPT menunjukkan adanya beda nyata kelompok K2 dengan pemberian kombinasi ekstrak dan pemberian parasetamol dibandingkan kelompok kontrol negatif (sig.<0,05). Oleh karena itu, dapat disimpulkan bahwa pemberian kombinasi ekstrak kunyit, jahe merah dan temulawak berbagai konsentrasi selama 20 hari memberikan pengaruh terhadap kadar SGOT dan SGPT sedangkan pada kadar Bilirubin total tidak memberikan pengaruh pada tikus putih akibat pemberian parasetamol. The cause of liver disorders or damage is due to the use of drugs that are hepatotoxic, this can be prevented by administering antioxidant compounds. The ability of antioxidants is able to protect biological systems against the potential of a toxic substance. The purpose of this study was to determine the effectiveness of extracts of turmeric, red ginger and temulawak as hepatoprotective in white rats. This study used an experimental method using a RAL experimental design (completely randomized design) with 2 control groups (positive and negative) and 3 treatment groups which were given paracetamol 162 mg/200 gram body weight and injected with a combination of extracts of turmeric, red ginger and temulawak with concentrations of 25% : 40% : 35%, 20% : 60% : 20% and 15% : 45% : 40% at a dose of 500 mg/kg BW. Data were analyzed using the One Way Anova test at α = 0.05 and continued with Duncan's test. The results showed that the levels of SGOT in rats that were given paracetamol and a combination of extracts of turmeric, red ginger and curcuma were in the range of 12.2-65.3 IU/L, while levels of SGPT were in the range of 5.3-13.08 IU/L and levels of Bilirubin the total is at 0.66-0.68 mg/dl. The results of the One Way Anova test in SGOT and Total Bilirubin levels did not show a significant difference between treatment groups (sig.> 0.05), SGPT levels showed a significant difference in the K2 group with a combination of extracts and paracetamol administration compared to the negative control group (sig.< 0.05). Therefore, it can be concluded that administration of a combination of extracts of turmeric, red ginger and temulawak at various concentrations for 20 days had an effect on SGOT and SGPT levels, while total bilirubin levels had no effect on white rats due to paracetamol administration

Item Type:	Thesis (Sarjana)
Additional Information:	1) Ns. Sri Rahayu, M.Biomed 2) Atin Supiyani, M. Si
Subjects:	Sains > Ilmu Bumi > Biologi
Divisions:	FMIPA > S1 Biologi
Depositing User:	Users 16876 not found.
Date Deposited:	03 Mar 2023 01:31
Last Modified:	03 Mar 2023 01:31
URI:	http://repository.unj.ac.id/id/eprint/37613

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