EFEK RADIOPROTEKTIF RESVERATROL TEMPE TERHADAP FREKUENSI MIKRONUKLEUS SEL SUMSUM TULANG MENCIT JANTAN AKIBAT RADIASI γ

ELIZABETH GABRIELLA ANGELITA, . (2023) EFEK RADIOPROTEKTIF RESVERATROL TEMPE TERHADAP FREKUENSI MIKRONUKLEUS SEL SUMSUM TULANG MENCIT JANTAN AKIBAT RADIASI γ. Sarjana thesis, UNIVERSITAS NEGERI JAKARTA.

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Abstract

*ABSTRAK* --------- Radiasi pengion telah banyak aplikasikan dalam dunia kedokteran, sebagai agen radioterapi. Paparan radiasi menyebabkan efek samping yang serius, menggangu kesehatan, terutama kerusakan DNA yang ditandai dengan terbentuknya mikronukleus. Resveratrol tempe, sebagai agen radioprotektif, dapat menurunkan frekuensi mikronukleus. Penelitian ini bertujuan untuk mengetahui pengaruh resveratrol tempe terhadap frekuensi mikronukleus pada sel sumsum tulang mencit jantan akibat radiasi gamma. Mencit dikelompokkan secara acak menjadi enam kelompok, yaitu kontrol, kelompok radiasi, kelompok resveratrol standar, kelompok resveratrol tempe, kelompok radiasi + resveratrol standar dan kelompok radiasi + resveratrol tempe. Resveratrol dosis 15 mg/kg berat badan diberikan secara oral selama dua hari dan 30 menit sebelum radiasi 3 Gy. Data diolah menggunakan Rancangan Acak Lengkap (RAL). Hasil menunjukkan bahwa paparan radiasi menyebabkan peningkatan signifikan frekuensi mikronukleus, dan setelah pemberian resveratrol tempe menyebabkan penurunan signifikan frekuensi mikronukleus pada sel sumsum tulang belakang mencit jantan. Hal ini dapat disimpulkan bahwa radiasi bersifat genotoksik sedangkan resveratrol tempe bersifat antigenotoksik dan dapat berperan sebagai agen radioprotektif terhadap sel sumsum tulang mencit jantan akibat radiasi gamma 3 Gy. *ABSTRACT* Ionizing radiation has many applications in medicine, such as a radiotherapy agent. Radiation exposure caused serious side effects, health problems, especially DNA damage which is characterized by the formation of micronuclei. Tempeh resveratrol, as a radioprotective agent, can reduce micronucleus frequency. This research was conducted to observe the effect of tempeh resveratrol on micronucleus frequency in bone marrow cells of male mice induced by gamma irradiation. Mice were divided into six groups randomly, control group, radiation group, resveratrol tempeh group, resveratrol standard group, radiation + resveratrol standard group and radiation + resveratrol tempeh group. Resveratrol was administered by orally with a dose of 15 mg/kg body weight for two days and 30 minutes before radiation. Data were processed using a Completely Randomized Design (CRD). The results showed that radiation exposure at a dose of 3 Gy caused a significant an increase in micronucleus frequency, and after administration of resveratrol tempeh caused a significant decrease in micronucleus frequency in the bone marrow cells of male mice. It can be concluded that radiation is genotoxic, while tempeh resveratrol is antigenotoxic. Resveratrol tempeh can role as a radioprotective agent against the bone marrow cells of male mice irradiated 3 Gy.

Item Type:	Thesis (Sarjana)
Additional Information:	1). Dr. Yulia Irnidayanti, M.Si. 2). Devita Tetriana, M.Si.
Subjects:	Sains > Sains, Ilmu Pengetahuan Alam Sains > Zoologi Sains > Fisiologi
Divisions:	FMIPA > S1 Biologi
Depositing User:	Users 19728 not found.
Date Deposited:	06 Sep 2023 05:57
Last Modified:	06 Sep 2023 05:57
URI:	http://repository.unj.ac.id/id/eprint/40985

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