Arfan, Alya and Rahman Habibi, Alif (2024) Molecular docking of Portulaca oleracea L. alkaloid compounds for potential antidiabetic activity through Cdk5 protein expression. Bioma, 20 (1). pp. 1-10. ISSN 0126-3552
Full text not available from this repository.Abstract
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine protein kinase, which forms the p35 or p39 active complex that is expressed predominantly in neurons. Cdk5 plays an important role in physiological functions in non-neural cells such as glucose-stimulated insulin secretion in pancreatic cells. This study aims to explore and determine the effectiveness of the chemical compound Oleracein E (OL-E) in the Portulaca oleracea (PO) as an anti- diabetic when expressed on Cdk5 protein. The test was carried out in silico with a computer- aided drug design method in which the molecular docking process used software such as Pyrx 0.8. The results of this study indicate that OL-E has the potential as an antidiabetic by inhibiting Cdk5 and has 27.65% better effectiveness than metformin in inhibiting Cdk5.
| Item Type: | Article |
|---|---|
| Subjects: | Sains > Ilmu Bumi > Biologi |
| Depositing User: | OJS LPPM UNJ . |
| Date Deposited: | 06 Mar 2025 00:35 |
| Last Modified: | 06 Mar 2025 00:35 |
| URI: | http://repository.unj.ac.id/id/eprint/54866 |
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