INDEKS ATEROGENIK PLASMA (IAP) DAN INDEKS RISIKO KORONER (IRK) MENCIT MODEL HIPERKOLESTEROLEMIA YANG DIINDUKSI VIRGIN COCONUT OIL (VCO)

THALITA ASRIANDINA, . (2022) INDEKS ATEROGENIK PLASMA (IAP) DAN INDEKS RISIKO KORONER (IRK) MENCIT MODEL HIPERKOLESTEROLEMIA YANG DIINDUKSI VIRGIN COCONUT OIL (VCO). Sarjana thesis, UNIVERSITAS NEGERI JAKARTA.

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Abstract

*ABSTRAK* Asam lemak trans jika dikonsumsi secara berlebih dapat menyebabkan hiperkolesterolemia yang ditandai dengan meningkatnya kadar kolesterol total >200 mg/dL. Hiperkolesterolemia dapat meningkatkan risiko terjadinya aterosklerosis yang merupakan penyebab utama Penyakit Jantung Koroner (PJK). Indeks Aterogenik Plasma (IAP) dan Indeks Risiko Koroner (IRK) merupakan parameter yang baik untuk memprediksi risiko terjadinya aterosklerosis dan PJK. Virgin Coconut Oil (VCO) telah diketahui memiliki potensi menurunkan kadar kolesterol. Tujuan dari penelitian ini adalah mengetahui pengaruh pemberian VCO terhadap nilai IAP dan IRK pada mencit hiperkolesterolemia yang diberi minyak trans. Metode yang digunakaan dalam penelitian adalah eksperimental. Sebanyak 25 ekor mencit jantan strain DDY berumur 6 minggu dibagi kedalam 5 kelompok perlakuan: (1) Kontrol (-) diberi saline 0,9%; (2) Kontrol (+) diberi minyak trans/MT 200 mg/kgBB; (3) MT+VCO 200 mg/kgBB; (4) MT+VCO 400 mg/kgBB; dan (5) MT+VCO 600 mg/kgBB. Pengukuran profil lipid darah menggunakan alat uji cepat Lipid Pro®. Profil lipid, nilai IAP, dan IRK dianalisis secara statistik dengan ANOVA (sig.<0,05) dan uji lanjut Duncan. Hasil menunjukkan pemberian VCO berpengaruh secara signifikan terhadap profil lipid darah mencit, nilai IAP, dan IRK (sig.<0,05). Konsentrasi VCO 600mg/kgBB adalah dosis optimal menurunkan risiko IAP dan IRK mencit hiperkolesterolemia dengan kategori risiko rendah. Pemberian VCO mampu menurunkan kadar kolesterol total, trigliserida, LDL darah serta nilai IAP dan IRK mencit hiperkolesterolemia yang diberi minyak trans selama 8 minggu. *ABSTRACT* Excessive intake of trans fatty acid may lead to hypercholesterolemia as indicated by total cholesterol levels >200 mg/dL. Hypercholesterolemia increases the risk of atherosclerosis which is the main cause of Coronary Heart Disease (CHD). Plasma Atherogenic Index (PAI) and Coronary Risk Index (CRI) are good parameters to predict the risk of atherosclerosis and CHD. Virgin Coconut Oil (VCO) has been known to have a potential to lower cholesterol levels. This study aims to determine the effect of VCO on PAI and CRI values in hypercholesterolemic mice given trans oil. The experimental design used in this study. A total of 25 male DDY strain mice aged 6 weeks were divided into 5 treatment groups: (1) Control (-) was given 0.9% saline; (2) Control (+) was given trans/MT oil 200 mg/kg; (3) MT+VCO 200 mg/kgBB; (4) MT+VCO 400 mg/kg; and (5) MT+VCO 600 mg/kg. Measurement of blood lipid profile using the Lipid Pro® rapid test kit. The values of lipid profile, PAI, and CRI were statistically analyzed by ANOVA (sig.<0.05) and Duncan's follow-up test. The results showed that the administration of VCO significantly affected the levels of profile lipid in the blood of mice as well as the PAI and CRI values (sig.<0.05). VCO concentration of 600mg/kgBW is the optimal dose to reduce the risk of PAI and CRI in hypercholesterolemic mice with low-risk categories. Giving VCO was able to reduce total cholesterol, triglycerides, blood LDL as well as PAI and CRI values of hypercholesterolemic mice given trans oil for 8 weeks.

Item Type:	Thesis (Sarjana)
Additional Information:	1) drh. Atin Supiyani, M.Si. 2) Dr. Tri Handayani Kurniati, M.Si.
Subjects:	Sains > Ilmu Bumi > Biologi Sains > Fisiologi
Divisions:	FMIPA > S1 Biologi
Depositing User:	Users 15861 not found.
Date Deposited:	05 Sep 2022 03:10
Last Modified:	05 Sep 2022 03:10
URI:	http://repository.unj.ac.id/id/eprint/34638

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